Effects of the P2-purinoceptor antagonist, suramin, on human platelet aggregation induced by adenosine 5′-diphosphate
نویسندگان
چکیده
منابع مشابه
Adenosine diphosphate-induced platelet aggregation in the states of hypercoagulability.
One hundred and seven patients with congestive heart failure, myocardial infarction and arteriosclerotic heart disease were studied by adenosine diphosphate-induced platelet aggregation, fibrinogen levels and ethanol gelation test. Both increases and decreases in platelet aggregation were observed. A significantly high percentage of patients showed a decreased platelet aggregation which was esp...
متن کاملThe P2Y1 receptor is necessary for adenosine 5'-diphosphate-induced platelet aggregation.
The human P2Y1 receptor heterologously expressed in Jurkat cells behaves as a specific adenosine 5'-diphosphate (ADP) receptor at which purified adenosine triphosphate (ATP) is an ineffective agonist, but competitively antagonizes the action of ADP. This receptor is thus a good candidate to be the elusive platelet P2T receptor for ADP. In the present work, we examined the effects on ADP-induced...
متن کاملThe P 2 Y 1 Receptor Is Necessary for Adenosine 5 8 - Diphosphate – Induced Platelet Aggregation
The human P2Y1 receptor heterologously expressed in Jurkat cells behaves as a specific adenosine 58-diphosphate (ADP) receptor at which purified adenosine triphosphate (ATP) is an ineffective agonist, but competitively antagonizes the action of ADP. This receptor is thus a good candidate to be the elusive platelet P2T receptor for ADP. In the present work, we examined the effects on ADP-induced...
متن کاملFurther observations on platelet aggregation induced by adenosine diphosphate thrombin and tri-ethyl tin.
Aggregation induced by adenosine diphosphate is inhibited by adenosine as well as by adenosine mono- and triphosphate. Thrombin-induced aggregation is also inhibited by adenosine and the monophosphate, but the triphosphate at a similar concentration is not inhibitory. Aggregation induced by tri-ethyl tin is accelerated by a critical concentration of triphosphate and delayed by a higher concentr...
متن کاملThe effect of vitamin E on the adenosine diphosphate induced platelet aggregation.
(1-4). These facts suggest that vitamin E may affect not only on blood coagulation but also on the platelet function. Recently, we found that ƒ¿-tocopheryl ace tate (referred as Toc-ac) inhibited time depen dant decrease of platelet number in the preser ved blood with EDTA-K2 as anticoagulant (5). In the present paper, the effect of Toc ac and ƒ¿-tocopheryl acetophosphate (Toc-acp) on the ADP i...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1992
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1992.tb14274.x